Trump's order on US drug prices: What's in it, and will it work? Why are American drug prices so high? Getty Images High drug prices have been a long-running source of dissatisfaction with the US healthcare systemWhat is Most Favoured Nation status? "Whether this will signal a durable and meaningful cut in extraordinarily high US drug prices is very unclear," he said. Meanwhile, it is unclear how lower prescription drug prices would fit into Kennedy's "Make America Healthy Again" agenda.