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AI Predicts Location of Virtually Any Protein Within a Human Cell

Saul Zimet

created: May 23, 2025, 6:52 p.m. | updated: May 27, 2025, 4:56 p.m.

“A protein located in the wrong part of a cell can contribute to several diseases, such as Alzheimer’s, cystic fibrosis, and cancer. But there are about 70,000 different proteins and protein variants in a single human cell, and since scientists can typically only test for a handful in one experiment, it is extremely costly and time-consuming to identify proteins’ locations manually. One of the largest such datasets is the Human Protein Atlas, which catalogs the subcellular behavior of over 13,000 proteins in more than 40 cell lines. But as enormous as it is, the Human Protein Atlas has only explored about 0.25 percent of all possible pairings of all proteins and cell lines within the database. Their method can predict the location of any protein in any human cell line, even when both protein and cell have never been tested before.”From MIT News.

1 month, 3 weeks ago: HumanProgress