From ancient remedies to your Amazon cart, mushroom supplements have traveled a circuitous road. Brands like RYZE and PlantFusion have played a significant role in transforming these fungi from traditional remedies to nootropic supplements. Are Mushroom Supplements Good for You? When’s the Best Time to Take Mushroom Supplements? Courtesy of Four SigmaticLike most supplements, timing your mushroom intake depends on the specific variety and what you're hoping to get out of it.