Most famously, she overcame the fourth-longest odds in UFC title fight history to submit Amanda Nunes. Here's one observer's ranking of the most impactful title fight upsets. A two-division UFC champion, he had made a career of fighting bigger men, including champions Georges St-Pierre, Matt Hughes and Lyoto Machida. Matt Serra (+850) defeats Georges St-Pierre by first-round TKOUFC 69, April 7, 2007This one is often cited as the biggest title fight upset in UFC history. "Rowdy Ronda" entered the Holm fight at 12-0 with 12 finishes, all but one of them coming in the first round.