An experimental obesity pill that works in a different way from the wildly popular Ozempic may help people lose weight, according to results from a small, preliminary human trial. But a new drug may be able to burn energy, and thus fat, without reducing appetite. Creatine-dependent thermogenesis refers to how the breaking down of creatine, particularly in fat cells, contributes to this heat and energy production. In the second part of the trial, they tested the drug in 24 participants with obesity for 15 days. They were also asked to fill out a questionnaire regarding appetite and satiety, and none reported a decrease in either.