Open Extended ReactionsAryna Sabalenka, winner of three Grand Slam singles, is the favorite to win her first Wimbledon title. Gauff and Keys both are among the top five choices at Wimbledon, according to ESPN BET odds. ESPN BET SPECIAL:Any American to win Women's tournament: +275In the 2024 women's final, Barbora Krejcikova defeated Jasmine Paolini to take home her first Wimbledon title and second Grand Slam title. Top seed Jannik Sinner, who successfully defended his Australian Open title before falling to Alcaraz in the French final, has the second-best odds. Seven-time Wimbledon winner Novak Djokovic, who has reached the final in six straight years, opened the tournament as the third choice.