How do pimple patches work? Updated July 2025: We’ve added Dearcloud Hydrocolloid Blemish Patches, CeraVe Hydrocolloid Blemish Patches, and Peach Slices Acne Spot Dots as new picks. Pimple patches come in various formulas, with different ingredients for different breakouts, but the most popular are hydrocolloid acne patches. How Do Pimple Patches Work? Photograph: Yuliya Sheynina/Getty ImagesAccording to most dermatologists, you can use pimple patches as needed.