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Human Babies Aren’t Supposed to Have 3 Parents—but Now They Can

created: July 22, 2025, 1 p.m. | updated: July 28, 2025, 5:37 p.m.

Here’s what you’ll learn when you read this story:The first babies with three biological parents were born out of a new technique to prevent mitochondrial disease. The nucleus of an egg fertilized in vitro was transferred into a donor egg without a nucleus, but with viable mitochondria. Eight healthy babies, including a set of twins, were born with low to undetectable levels of mitochondrial mutations. They were previously only preventable by using a donor egg or foregoing the conception of biological children altogether. Levels of defective mitochondria in offspring conceived via pronuclear transfer were low enough to escape that fate.

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