Biomedical engineers have achieved a major breakthrough in organoid research, pushing us closer to a new era of neurophysiological analysis and treatments. A team at Johns Hopkins University has created some of the first whole-brain organoids that include interconnected, functional tissues from each region of the human brain. Brain organoid development is one of the most promising, complex, and often surreal biomedical frontiers. This is largely due to the fact that most biomedical researchers currently rely on animal models during early development stages. Swapping out lab rats for whole-brain organoids that more closely resemble a natural human brain will likely offer quicker, better results.