Having a dehumidifier will make humid days more tolerable, but if you miss your monthly cleaning, the machine won't work as well. When the musty, wet air makes it into your home, the best way to avoid discomfort is to run a dehumidifier. #3: Clean the coilsWith the outer components clean, it’s time to roll up your sleeves. Dehumidifier FAQsHow often should I clean my dehumidifier? Cleaning your dehumidifier is one of those low-effort, high-reward maintenance tasks to prevent breakdowns.