An experimental pill made by Eli Lilly led to average weight loss of more than 12 percent of body weight in individuals with obesity, according to initial trial results announced by the drugmaker on Thursday. Injected GLP-1 drugs have shown weight loss of around 15 to 20 percent. Novo Nordisk has a GLP-1 pill for diabetes, Rybelsus, but it’s not as effective for weight loss as injectable versions and was never approved for weight management. Novo Nordisk has a GLP-1 pill for diabetes, Rybelsus, but it’s not as effective for weight loss as injectable versions and was never approved for weight management. Other GLP-1 drugs are made up of larger molecules that are not easily absorbed in the gastrointestinal tract.