Reigning champions Liverpool are the favorites to win the Premier League for 2025-26, showing +175 odds at ESPN BET. Arsenal, the runners-up last season, are second favorites at +225 with Man City rounding out the top three at +350. Liverpool are the favorites to win the Premier League among bettors in the United States. The Premier League is easily the most-bet soccer league at American sportsbooks, with BetMGM saying it accounts for 80% of its league-winner wagers among the Big Five European leagues. On a match-to-match basis, the Premier League attracts twice the amount of tickets and money as the closest league, LaLiga.