
Theolytics to Present Ongoing Phase I/IIa OCTOPOD-IV Trial of THEO-260 in Ovarian Cancer at ESMO 2025
created: Oct. 13, 2025, 8 a.m. | updated: Oct. 14, 2025, 9:27 a.m.
Dr Margaret Duffy, CSO and Dr Matilde Saggese, CMO will be attending and will showcase the OCTOPOD-IV Phase I/IIa clinical trial of THEO-260, a novel oncolytic immunotherapy, given by intravenous delivery in patients with ovarian cancer.
OCTOPOD-IV (NCT06618235) is a first-in-human, multi-centre trial to assess safety, tolerability and preliminary efficacy of THEO-260 in patients with high-grade serous ovarian or endometrioid cancer.
Matilde Saggese, MD,MD (Res), Theolytics’CMO,said,“Recruitment is now well under way for our first ever clinical trial with THEO-260.
THEO-260 is being evaluated in a Phase I/IIa clinical trial by intravenous delivery in ovarian cancer patients (OCTOPOD-IV) (NCT06618235).
A clinical study of THEO-260 administered by intraperitoneal delivery to advanced ovarian cancer patients (OCTOPOD-IP) is also underway in the US in collaboration with The University of Texas MD Anderson Cancer Center (NCT07211659).
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