Of course, the Niners will face far tougher tests against the Bears and Seahawks than they did against Indianapolis. Here's what to know from both teams after the 49ers beat the Colts on Monday night:The 49ers beat the Colts 48-27 on Monday night. But Purdy shrugged those woes off against a depleted Colts secondary, posting his first career five-touchdown game. But San Francisco's offensive line was up to the task with running back Christian McCaffrey enjoying his second-best rushing effort of the season. While Rivers held up his end, the Colts' defense had its most miserable performance of the season.