In 2026, we will see the beginning of precision medical forecasting. These added layers of data can be combined with a person’s electronic medical records, which include their structured and unstructured notes, lab results, scans, genetic results, wearable sensors, and environmental data. In aggregate, this provides an unprecedented depth of information about the person’s health status, enabling a forecast for risk of the three major diseases. The potential for precision medical forecasting has to be demonstrated and validated via prospective clinical trials that show, using the same metrics of aging, that a person’s risk is decreased. This is a new frontier in medicine—the potential for primary prevention of the three age-related major diseases that compromise our health span and quality of life.