A Rule of Chemistry Stood for 100 Years. Now, Scientists Have Broken It—Twice.
created: Jan. 29, 2026, 1 p.m. | updated: Feb. 3, 2026, 5:52 p.m.
Here’s what you’ll learn when you read this story:Double bonds, or alkenes, are not supposed to form in some locations on organic molecules, which is known as Bredt’s rule.
Researchers who successfully broke that rule last year have now synthesized even weirder molecules that exist in three dimensions.
The rule was broken by UCLA chemist Neil Garg and his research team around 100 years later.
Most molecules connected by alkene bonds (i.e.
With two rules of organic chemistry already broken, Garg plans to continue studying these molecules and their possible applications—especially what they could possibly do for the pharmaceutical industry.
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