Now, you can find PDRN in all kinds of skincare products ranging from eye creams to sunscreen. I’ve used two bottles of Rejuran’s topical ampoule and other skincare products marketing hot new ingredients like volufiline, because that’s the power of science-adjacent wellness marketing. So I asked Fu if any of the claims about topical PDRN being as effective as injected skincare treatments held water. “There’s some early research supporting PDRN in medical and aesthetic procedures, but evidence for topical PDRN is still very limited,” says Fu. Having spent the past three months slathering a salmon sperm serum on my face, I honestly couldn’t tell you if it’s improved my skin.