We break down the best way to keep your mattress clean and fresh. As is the case with most cleaning projects, the best first step is investing in a mattress cover. The Vacuum Is Your Best Friend When Mattress CleaningTo clean a mattress, simply remove the mattress cover and go over the entire surface with your vacuum. To spot clean your mattress, stick with non-toxic products like , and make sure your mattress properly dries before placing a cover or sheet back over it. Top Products We Recommend For Mattress Cleaning